Feb 24, 2015 the cedex bio analyzer is an efficient, mediumthroughput analyzer that currently permits the rapid measurement of sodium and potassium through one module ionsensitive electrode, and nutrients and metabolites such as glucose, lactate, ammonia, ldh, glutamine, glutamate, igg, and acetate through the second module photometric analysis. Cedex bio analyzer bioprocess analyzer roche custombiotech. Cedex bioprocess analyzers for vaccine manufacturing. Cedex bio analzyer from roche custombiotech youtube. No manual dilution is required before applying samples to cedex bio analyzers. Gain insights in improved ways of monitoring and analyzing cell culture with three bioprocess analyzers of the roche cedex analyzer family. Ldh as a parameter for cell death is unique in the metabolite profiling. Cedex bio ht analyzers has been proven for all assays. Calibrator b bio calibrator reagent for the cedex bio and.
Download roche cedex bio operators manual manualslib. Nova biomedical develops, manufactures, and sells advanced. In addition, the application of cedex bio ht as a tool for microbial. Apr 29, 2015 during the awards, roche custom biotech received the best technological development award for their line of cedex bioprocess analyzers, comprised of the cedex bio and cedex bio ht. Pdf utilizing roche cedex bio analyzer for in process. Tight bio process control is decisive for optimal yields. The cedex bio ht is recommended for high throughput screening.
The cedex bio analyzer combines three devices to one with. Automated sample dilution saves time and ensures high accuracy. Cedex bio ht analyzer automated monitoring of bioprocesses. Technical document resource more than 800,000 documents available on demand for centralized diagnostics, tissue diagnostics, molecular diagnostics, life science, sequencing and custom biotech product information. Cedex bio ht manual keyword found websites listing keyword.
The cedex bio analyzer is a multianalyzer for monitoring bioprocesses and fermentations. If hplc is the gold standard what are the advantages of. The cedex bio and cedex bio ht analyzers provide access to 21 assays. Download documentation like operator manual or instructions for use method sheets on elabdoc. Application of the roche cedex bio analyzer in the culture. Example opc genie configuration for cedex analyzers. The analysis of substrates, metabolites and products can be measured both photometric and. Cedex bio automated bioprocess analyzer wolf cell sorter gentle microfluidic cell sorting technical service. Roche supplies reliable systems for all types of inprocess control of fermentation processes using mammalian and microbial cells in the form of its cedex bio analyzer for lowthroughput and its new cedex bio ht analyzer for highthroughput applications. The analyzer uses the wellestablished trypan blue exclusion method and a high resolution image scanner to analyze cells and. View online or download roche cedex bio operators manual. Advance the potential of your cell culture and discover roche custombiotech inprocess control solutions for use in quality. Cedex bio ht analyzer from roche custombiotech youtube. Paperless and always uptodate with 247 access, use your customer login to gain access to bulletins, operator manuals, and o.
In apbt, the samples are mixed with a set of reagents for the enzymatic reactions, and their absorption levels are measured by a photometric measurement unit to quantify the metabolite concentrations, which differentiate it from other. This is an example opc genie configuration for cedex analyzers designed to communicate with cedex analyzers. Roche evaluationdata cedex bio ht analyzer cedex bio analyzer y 1. The correct environmental conditions are an essential factor in the cultivation of microorganisms. Mar 15, 20 no manual dilution is required before applying samples to cedex bio analyzers. The reactor is equipped with a ph and a po2 probe and supplied with air, o2, co2 and n2 to control disolved o2 and co2.
Product quality was assessed with respect to antibody charge, glycan profile, aggregate, and fragment proportion. Roche cedex bio system operators manual pdf download. High accuracy, less variation between samples operating convenience and ease of use flexible plugandplay reagent format. Roche roche launches new metabolite tests for its cedex bio. This manual is for users of the cedex bio analyzer running software version 2. Sep 01, 2011 the cedex bio analyzer was developed utilizing the proven cobas instrument technology from roche. Product titer, nutrients, and metabolites were all measured on a cedex bio analyzer. The cedex hires analyzer is a fully automated, imagebased cell analyzer providing information about cell concentration, viability, aggregates, and morphological parameters, such as cell diameter and cell compactness. Roche now supplies reliable systems for all types of inprocess control of fermentation processes using mammalian and microbial cells in the form of its cedex bio analyzer for lowthroughput and its new cedex bio ht analyzer for highthroughput applications. Roche launches new metabolite tests for its cedex bio. Materials and methods setup the setup consists of a 3. We have 1 roche cedex bio ht manual available for free pdf download.
The analyzer uses the wellestablished trypan blue exclusion method and a high resolution image scanner to analyze cells and objects. Oct 30, 2012 the cedex bio ht analyzer sets a new gold standard in bioprocess analytics. Automated dilution reduces operator dependent manual steps and variability. This example helps you to communicate between your hmi, historian, mes. Availability in the direct environment of the bioreactors providing results within minutes. Cedex bio measuring instruments pdf manual download. Roche cedex bio operators manual pdf download manualslib. The cedex bio ht is an automated analyzer for determination of substrates, metabolites and products in aqueous solutions like cell culture and fermen. With a broad test portfolio, cedex analyzers provide precise information about the nutrient, metabolite and product status of cultures, as well as cell viability and growth rate. Scaling a mab production process to xcellerex bioreactors. Roche roche launches new cedex bio ht analyzer for cell.
Glucose monitoring and control using numera, lucullus pims. Cholesterol cho2b, cho2d glutamine glnb, glnd ldh ldh2b, ldh2d nh3 nh3b, nh3d use this calibrator as described in the instructions of the respective assay. Complete solution with enhanced ease of use effectively handle complex workloads on a. Advance the potential of your cell culture and discover roche custombiotech inprocess control solutions for use in quality control manufacturing process. Page 6 cedex bio system conventions used in this manual visual cues are used to help locate and interpret information in this manual quickly. System reagent for the cedex bio and cedex bio ht analyzers.
Utilizing roche cedex bio analyzer for in process monitoring. The flownamics segflow 4800 coupled with the cedex bio ht bioprocess analyzer provides automated, online analytical solutions for advanced bioprocess culture monitoring. The anoxomat iii is a flexible jar system that allows you to define anaerobic, microaerophilic or capnophilic environments for your cultures. Numerous samples can be processed simultaneously with minimal manual intervention. Statstrip lachbhct fingerstick capillary blood testing for lactate, hb, and hct. Table 1 measurement ranges current methods versus cedex bio parameter current methods cedex bio cedex bio wo dilution automated dilution glucose mgl 200 15. Comparison of the cedex bio and cedex bio ht analyzer showing the same recovery of glucose. Download documentation like operator manual or instructions for use. Complete solution with enhanced ease of use effectively handle complex workloads on a single platform. Every effort has been made to ensure that all the information contained in this manual. Manual sample preparation filtration, protein precipitation, etc. Despite those benefits, this turbidimetric method brings some drawbacks. You can reach your contact under the following number. Measuring instruments roche cedex bio system operators manual 496 pages.
Utilizing roche cedex bio analyzer for in process monitoring in. With a broad test portfolio, cedex analyzers provide precise information about the nutrient, metabolite and product status of. Pdf utilizing roche cedex bio analyzer for in process monitoring. Cedex bio ht analyzer bioprocess analyzer roche custombiotech. Related manuals for roche cedex bio measuring instruments roche cedex bio system operators manual 496 pages measuring instruments roche cedex hires operators manual 166 pages. The cedex bio and bio ht analyzers provide results of high accuracy, comparable to the more laborious gold standard methods like hplc with added advantages including. Our lab was an early adopter, purchased the very first cedex bio in the state of ct after its release 7 years ago, and its still a workhorse in our cell culture workflow. Page 2 50 samples per day, utilizing photometric analysis and a unit for ion selective electrodes ise. Page 1 cedex bio analyzer operators manual software version 2. Realtime titer measurement during continuous antibody. If hplc is the gold standard what are the advantages of the.
Cedex bio and bio ht analyzers improved workflow efficiency. Automated benchtop chemistry analyzer number of channels reagent slots. Jul 03, 20 adding iron and phosphate tests to cedex bio test menu. Advance the potential of your cell culture cedex bio and. The award recognized that by the application of these instruments in vaccine manufacturing, users were able to gain valuable information about the health and. The cedex bio analyzer is recomended for use in low throughput environment. As a lab head with years of frustration using membrane based analyzers, the roche cedex is lightyears ahead in technology and the consumable cost is lower. Deliver fast, accurate and reliable analytical process data with the cedex bio analyzer. Advance the potential of your cell culture and discover roche custombiotech inprocess control solutions for use in quality controlmanufacturing process onl. This product is intended for calibration of quantitative assays of the cedex bio and cedex bio ht analyzers for the following tests. This manual describes the cedex bio system features and general operational concepts, and it provides operating, maintenance, and emergency procedures. Cedex hires analyzer from roche custombiotech youtube. We are a service company specializing in the sale of refurbished analytical chemistry, biological and pharmaceutical, and environmental laboratory as well as medical equipment.
Find manuals, certificates of analysis and method sheets on support portalroche elabdoc. Advance the potential of your cell culture and discover roche custombiotech in process control solutions for use in quality. Autosampling solution for cedexbio ht bioprocess analyzers. Feed control options control 2 feed pumps per vessel setpoint control, gravimetric feed control other feed algorithms can be programmed.
Roche cedex bio operators manual pdf download manualslib page 1 cedex bio analyzer operators manual software version 2. Cambridge scientific has access to thousands of biotechnology and pharmaceutical companies, as well as hospitals, universities and colleges giving us access to a wide selection of high quality used laboratory equipment. Its precise test results and high data consistency help to create optimal conditions for fermentation processes, which in turn result in high product quality and yield. Roche evaluation data cedex bio ht analyzer cedex bio analyzer y 1. View and download roche cedex bio operators manual online. The right instrument for improved workflow efficiency. Roche launches new cedex bio ht analyzer technology networks. Host interface manual roche cedex bio ht host interface manual 202 pages.
Application of the roche cedex bio analyzer in the culture of. The online application of this device for online cell culture monitoring and process control is a current topic of research. An automated dilution increases the measurement ranges and reduces operator variability because no manual dilution is needed before. Narrow your search to look for specific document types, including application notes, manuals, protocols, and brochures.
Search for a variety of documents via title or keyword. The manual colony counter dot makes it easy to count colonies on petri dishes in the microbiology. Automated computerized analyzer for determination of a wide range of analytes in aqueous solutions like cell culture and fermentation media. The statstrip lactate and hemoglobinhematocrit meter system statstrip lachbhct is a handheld, easytouse meter system that measures lac, hb and hct at the pointofcare using two disposable biosensors and tiny capillary blood samples for all tests. Roche launches new metabolite tests for its cedex bio systems. Roche cedex bio ht roche cedex hires cell analyzer ysi 2700, 2900, 2950, and 7100 biochemistry analyzers. The wide range of measurable parameters allows the use of the cedex bio to monitor the production as well as to develope and optimize growth conditions for mammalian, bacteria and yeast culture systems. The segflow samples from 1 to 8 vesselsprocess streams and delivers each sample to the cedex bio ht, or up to 4 analyzers. Product quality was analyzed on samples taken on day 7 and at harvest day. Cedex bio ht manual keyword found websites listing. The cedex bio analyzers in combination with the cedex hires analyzer offer exceptional data reliability and nearautomated integration during the cell fermentation process. Roche roche launches cedex bio bioprocess analyzer for.
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